Sigachi US Inc.

Reisterstown,  MD 
United States
http://www.sigachi.com
  • Booth: 1053

 

Sigachi is a leading manufacturer of high-quality excipients for the pharmaceutical Industry. With nearly 30 years of experience and three multilocational facility, Sigachi is among the top manufacturers of Microcrystalline Cellulose. Our products are available with Drug Master File. Our facilities are EXCiPACT GMP, WHOGMP, HACCP and ISO 9001:2015 certified. We have CEP (Certificate of Suitability) from EDQM.  Range includes Microcrystalline Cellulose, Cellulose Fibre,  Colloidal grades of MCC, Other Co-processed grades like SMCC, CE and Cros Carmellose Sodium. For further details, visit www.sigachi.com 

Brands: HiCel, AceCel, HiCel MCG, HiCel CE15. HiCel SMCC, AceFibre, HiLose(Cros Carmellose Sodium)


 Products

  • HiCel™ 50M
    Because of its small particle size, can be used for both wet and dry granulation. Effective when used with large particles because of its binding properties. Primary use is in the wet granulation applications.
    ...

    • As a Strong, dry binder
    • High dilutionpotential
      •  good compressibility
      • broad particle size distribution
      • low bulk density
    • Provides for high tablet hardness at low pressure
      • high porosity
      • plastic deformation
    • Facilitates low tablet friability, promotes rapid tablet disintegration
    • Good flowability
    • Less glidant requirement
    • Lower tablet weight variation
    • Antiadherent and inherent lubrication, can reduce lubricant requirement
  • HiCel™ 90M
    Has larger particle size, improved flowability, especially with smaller particle size components. Most popular grade of MCC used in direct compression.
    ...

    • As a Strong, dry binder
    • High dilutionpotential
      •  good compressibility
      • broad particle size distribution
      • low bulk density
    • Provides for high tablet hardness at low pressure
      • high porosity
      • plastic deformation
    • Facilitates low tablet friability, Promotes rapid tablet disintegration
    • Good flowability
    • Less glidant requirement
    • Lower tablet weight variation
    • Antiadherent and inherent lubrication, can reduce lubricant requirement
  • HiCel™ LP200
    Large particle size used with poorly flowing actives. Improves flowability & facilitates high speed tableting of direct compression blends and reduces tablet weight variation.
    ...

    • As a Strong, dry binder
    • High dilutionpotential
      •  good compressibility
      • broad particle size distribution
      • low bulk density
    • Provides for high tablet hardness at low pressure
      • high porosity
      • plastic deformation
    • Facilitates low tablet friabilityPromotes rapid tablet disintegration
    • Good flowability
    • Less glidant requirement
    • Lower tablet weight variation
    • Antiadherent and inherent lubrication, can reduce lubricant requirement
  • HiCel™ SMCC 90M
    HiCel™ SMCC is silicified microcrystalline cellulose, a combination of 98% microcrystalline cellulose (MCC) and 2% colloidal silicon dioxide (CSD). HiCel™ SMCC has unique combination which result in optimum compaction and superior flow properties....

    • Superior flow characteristics
    • Tablet binder in direct compression where optimum flow is required
    • As a filler in capsule
    • Low dose content uniformity
    • Dust free handling
    • Insoluble in water and inert in nature
    • Consistent and stable ingredient
    • Excellent compactibility
    • Excellent binding characteristics due to higher surface area
    • Improved lubrication properties results in excellent blend homogeneity and content uniformity
    • Increased production capacity while lowering stress on equipment
    • Smaller tablet size with shorter disintegration time
  • AceCel™ 101
    The average particle size varies from 50 to 60 Microns & is well suited for wet granulation, roller compaction and spheronization.
    ...

  • This grade is Air Stream Dried and thereafter mechanically disintegrated to attain the desired physical properties and size. The average particle size varies from 50 to 60 Microns, with bulk density ranging from 0.27 to 0.32 gm/CC.
  • AceCel™ 102
    This grade is Air Stream Dried and thereafter mechanically disintegrated to attain the desired physical properties and size. The average particle size is 100 Microns, with bulk density ranging from 0.27 to 0.32 gm/CC....

  • AceCel 102 is a medium particle size standard  MCC grade, with an average particle size of 100 Microns. This grade is mostly suited for directly compressible actives. 
  • HiCel™ MCG591
    As a thickener. Use in oral suspensions as a stabilizer and emulsion prepared with high shear forces. Used in sprays. It binds ingredients together and increases the mechanical strength of the tablet, thus preventing flaking of the tablet during pressing....

  • HiCelTM MCG is a co-processed spray dried blend of Microcrystalline Cellulose (MCC) and Carboxy methyl cellulose sodium (Na-CMC). HiCelTM MCG when dispersed in water under high shear mixing, NaCMC act as a protective colloid by forming a viscous and thixotropic gel. The wide range of viscosities, gel strength and dispersion characteristics of HiCelTM MCG make it suitable for suspension stability.  
  • HiCel™ MCG581
    HiCel™ MCG581 is a co-processed spray dried blend of Microcrystalline Cellulose (MCC) and Carboxy methyl cellulose sodium (Na-CMC). When dispersed in water NaCMC act as a protective colloid by forming a viscous and thixotropic gel.
    ...

  • For ready to use suspensions and emulsion prepared with high shear forces. Accelerates disintegration and dispersion.
  • HiCel™ MCG611
    Ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient
    Excellent water uptake capacity
    Excellent stabilizer and thickener...

  • HiCelTM MCG is a co-processed spray dried blend of Microcrystalline Cellulose (MCC) and Carboxy methyl cellulose sodium (Na-CMC). HiCelTM MCG when dispersed in water under high shear mixing, NaCMC act as a protective colloid by forming a viscous and thixotropic gel. The wide range of viscosities, gel strength and dispersion characteristics of HiCelTM MCG make it suitable for suspension stability.  

    Viscocity - 60 – 140, (2.6% solution)

  • Hilose™
    HiloseTM, is an internally cross linked polymer of carboxymethyl cellulose sodium which is used as a super disintegrant in formulations. Cross Linking makes it insoluble, highly absorbent material resulting in excellent swelling properties.
    ...

  • HiloseTM, is an internally cross linked polymer of carboxymethyl cellulose sodium which is used as a super disintegrant in pharmaceutical formulations. Cross Linking makes it insoluble & highly absorbent material, resulting in excellent swelling properties. Its unique fibrous nature gives it excellent water wicking capabilities.

    Benefits: 

    • Rapid swelling characteristics
    • Superior flow property
    • Good stability with API
    • Long term stability
    • Fast tablet disintegration
    • Fast drug dissolution
    • Economical

    Applications:

    • Used in oral pharmaceutical formulations as a super disintegrant for Capsules, Tablets and Granules Formulations.
    • Used in tablets including dietary supplements to assist the tablet in disintegrating in the intestinal track.
    • In tablet formulations, it is used in both direct compression and wet granulation processes.
    • Effective in combination with both insoluble filler-binders and slightly soluble to soluble filler-binder.
    • Used in wet granulations as intra granular or extra granular super disintegrant.
  • HiCel™ CE15
    HiCel CE15 is a co-processed grade of microcrystalline cellulose and guar gum. This free flowing co-processed blend results in dramatic differences primarily in the areas of overall sensory experience and perceived taste when compared to other products....

  • Advantages: 

    • Less grittiness
    • Minimal chalkiness
    • Lower friability
    • Reduced tooth packing
    • Improve creamier mouth feel
    • Improved overall palatability

    Applications: 

    Chewable tablet (Antacid)

    Chewable tablet (Asprin)

    Chewable tablet (Acetaminophen)

  • HiCel™ SMCC HD 90M
    HiCelTM SMCC HD 90M is silicified microcrystalline cellulose, a combination of 98% microcrystalline cellulose (MCC) and 2% colloidal silicon dioxide (CSD). Applications include high dose capsule filling, better tablet disintegration & increased batch size...

    • Ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient
    • Superior flow characteristics
    • Dust free handling
    • Insoluble in water and inert in nature
    • Consistent and stable ingredient
    • Excellent compactibility
    • Excellent binding characteristics due to higher surface area
    • Improved lubrication properties results in excellent blend homogeneity and content uniformity
    • Increased production capacity while lowering stress on equipment
    • Smaller tablet size with shorter disintegration time
  • AceCel™ 112
    AceCel™ 112 is the same as AceCel 101 with very low moisture. The moisture content is <1.5%. This is primarily used for processing water sensitive actives....

  • This grade is well suited for wet granulation, roller compaction and spheroniation. AceCel™ 112 is a medium particle size standard  MCC grade, with an average particle size of 100 Microns. This grade is mostly suited for directly compressible actives which are moisture sensitive in nature. 
  • HiCel™ XLM 90
    HiCel 90M is mostly used for Direct Compression. It's average particle size is 90 Microns. Due to low moisture content (<1.5%). It is recommended for extremely moisture sensitive active ingredients.
    ...

  • The HiCel brand of MCC is byfar the most consistent brand in the Microcrystalline industry. HiCel is manufactured by the Spray Drier route only and boasts of results and parameters superior to the best in the market. Below are its key benefits of HiCel XLM 90M

    • As a Strong, dry binder
    • High dilution potential
      •  good compressibility
      • broad particle size distribution
      • low bulk density
    • Provides for high tablet hardness at low pressure
      • high porosity
      • plastic deformation
    • Facilitates low tablet friability
    • Promotes rapid tablet disintegration
    • Good flowability
    • Less glidant requirement
    • Lower tablet weight variation
    • Antiadherent and inherent lubrication, can reduce lubricant requirement