• Booth: 233

CSIRO is Australia's national research body. At CPhI, we're showcasing

  • our RAFT controlled polymerization technology, to make surface coatings, sustained release, and bio-conjugation a breeze.
  • FloWorks, our continuous flow chemistry facility, used to convert batch processes into continuous ones, reducing power consumption, waste stream, and footprint.
  • 3D metal printed catalytic static mixers (CSMs) coated in catalysts (Pd/Pt/Rh) are used as inserts for our flow reactors removing the need to filter Pd-C slurries.
  • Intelligent membranes using MOFs with slow-age properties help with continuous filtration and pervaporation.

Brands: CSM, RAFT, FloWorks, MofWorx


  • Catalytic Static Mixers
    Metal 3D-printed static mixers coated in catalysts like Pd,Ni,Co,Pt,Rh replace fixed bed and catalyst slurries....

  • CSMs - Catalytic Static Mixers

    Drawing on the multi-disciplinary expertise at the CSIRO, we have delivered a new method for heterogeneous catalytic reactions - catalytic static mixers (CSMs). With simple and well established design this innovative solution aims to provide an elevated approach to tubular reactor technology. Using 3D printing capabilities, novel metal scaffolds are designed and manufactured before the catalyst is directly deposited via electroplating, cold spraying, or other deposition methods. The CSMs can be readily inserted into reactor tubes, allowing for easy changeover of catalyst. The benefits of utilising metal scaffolds, which have good mechanical stability, are significant and include:


    In comparison to most catalyst bed systems, temperature within the newly designed CSM reactors are far more controllable. The design of the mixers ensure that pressure drop is low and mixing is efficient.


    One of the main benefits of 3D printing is the flexibility of design. The static mixer geometry can be designed specific to the needs of each project, taking into account the properties of the reagent mixture and the fluid flow. Flow maldistribution, concentration and temperature hotspots can be avoided.


    Using in house design and manufacture, tailor made 3D printing of metal mixers for tubular flow chemistry reactors can be several times cheaper than commercial static mixers of similar dimensions.


    CSM reactors can be easily adapted to current manufacturing processes. This ensures that past manufacturing methods do not need to be altered in order to utilize this technology, making the process more fluid and accessible.

    We have used this approach to prepare CSM reactors and tested them in hydrogenation (gas-liquid) and transfer hydrogenation (homogenous liquid) reactions. High Turn-Over-Frequencies and Space-Time-Yields were achieved without detectible leaching of the catalyst metal.

  • Intelligent Membranes
    Novel mixed matrix pervaporation membranes - Water removal from organic reaction media in continuous processes....

  • CSIRO Intelligent Membranes

    Novel mixed matrix pervaporation membranes

    Pharmaceutical processes for the synthesis of small active pharmaceutical ingredients often require anhydrous conditions. Residual water in reaction medium is typically removed by distillation. However, this technology is expensive and may not be suitable for thermally unstable compounds. We are developing novel methods to remove water from organic solvents and organic reaction media that would be suitable for the continuous manufacture of pharmaceuticals.

    The high performance membranes are a key to effective use of pervaporation technology. CSIRO has extensive research experience and expertise on mixed matrix membranes for gas and liquid separations involving the use of porous additives such as metal-organic frameworks (MOFs) to overcome permeation difficulties and more importantly aging (see Figure above). We have developed two types of mixed matrix membrane materials which exhibited high performance towards either solvent or water with high separation factor and could be potentially used for either solvent concentration or dehydration.

    We aim to demonstrate the potential application of a novel hydrophilic mixed matrix membrane exhibiting high performance towards water removal from organics with high separation factor and stable at a wide range of pH environment. Mixed matrix membrane will consist of a polymeric matrix and appropriate loadings of nano-addtives. The nano-additives could be inorganic nanoparticles (SiO2 or TiO2), MOF or graphene. The incorporation of the specific nano-additives could enhance the water transport properties of the membrane while achieving high water organic separation.

  • Polymers on tap
    Using the latest in synthesis and process technologies, CSIRO can design and synthesise well-defined polymers to meet the needs of industry. From the team that brought you RAFT and nitroxide-mediated polymerisation....

  • Polymers on tap

    Polymer science at CSIRO

    CSIRO Manufacturing has broad multidisciplinary capability in chemical synthesis with skills and expertise in design, synthesis, characterisation and process development. Our Industrial Polymers Team combines its expertise in polymer chemistry, synthetic chemistry, polymer analysis and characterisation to create precisely engineered polymers. CSIRO research in polymer science includes world-leading capabilities, such as:

    • Controlled free radical polymerisation

    • Reactive extrusion

    • Condensation polymerisation

    • Biomedical polymer synthesis

    • Polymer processing.

    Our polymer capability is underpinned by our strength and track record in small molecule synthesis.

    What does CSIRO offer?


    CSIRO can provide bespoke turnkey solutions for polymer design and manufacture.


    CSIRO provides a fully integrated service, including:

    • R&D services
    • process development, and
    • pilot-scale manufacture through our partner BoronMolecular www.boronmolecular.com

    Our research activities are supported by modern scale-up facilities, including temperature controlled batch reactors with capacities ranging from 10 to 450 L. As well FloWorks, CSIRO’s new Centre for Industrial Flow Chemistry provides access to cutting-edge R&D into industrial processing. The centre operates state-of-the-art flow chemistry technology for the development of chemical manufacturing processes. The facility combines capabilities for the discovery of new chemical routes in the laboratory. It also allows for reaction optimisation under manufacturing conditions and final process scale-up to pilot and production scale.

  • FloWorks
    CSIRO’s Centre for Industrial Flow Chemistry. Using the latest in flow chemistry and process technology, CSIRO can provide manufacturing solutions to rapidly synthesise small molecules and polymeric materials....

  • FloWorks - CSIRO’s Centre for Industrial Flow Chemistry

    FloWorks is a state-of-the-art facility providing access to CSIRO’s cutting-edge research into industrial processing for Australian and international chemical manufacturers. Flow chemistry reactors are a safe, efficient, cost-saving and reliable alternative to conventional batch apparatus for chemical processing.

    FloWorks provides a range of different services, including:

    • Processing R&D operations at CSIRO for a wide array of client applications

    • Managing technology transfer to the client’s site

    • In-house training for industrial collaborators on the centre’s flow chemistry and process equipment.

    Continuous flow processing

    Flow chemistry reactors consist of either tubular pipes or channelled plates. Chemical reactions take place
    in a continuous stream within these highly controlled environments.

    • Better process control resulting in higher product yields & purities, shorter reaction times, and less waste

    • Better scalability due to compact, efficient and modular reactor design

    • Smaller physical footprint resulting in reduced capital, operating & maintenance costs

    • Superior inherent safety resulting in lower risk and environmental impact

    • Superior mixing, enhanced heat and mass transfer, wide pressure and temperature operation windows

    • ‘Plug and Play’ modular equipment

    Flow chemistry makes chemical production safer, more reproducible and scalable while offering reduced cost and low environmental impact.

    Innovative chemical manufacture

    FloWorks designs and creates new molecules and polymers with specific properties and functions.

    Using our expertise, we can develop the chemical route and the process technology for a wide range of applications in different manufacturing industries including:

    • Fine & Speciality Chemicals
    • Polymers
    • Pharmaceuticals & Health Care
    • Agrochemicals
    • Food Additives
    • Biofuels & Renewable Materials
    • Nanomaterials


    FloWorks operates a broad range of continuous flow reactors and chemical process equipment, ranging from a few mL
    to several Litres in reactor volume. We work closely with commercial equipment suppliers to optimise reactor design and process efficiency by:

    • Devising chemical processes using off-the shelf reactor solutions from one of our collaborating equipment manufacturers

    • Designing new tailor-made chemical reactors, dedicated for a specific operation

    • Developing novel reactor concepts for a range of common chemical processes, such as heterogeneous catalysis and multi-phase reactions

  • Small molecule discovery collection
    CSIRO has a proprietary small-molecule collection comprising over 40,000 unique, mainly low molecular weight heterocyclic molecules....

  • Small molecule discovery collection

    The samples are physically available in our cold storage facility (4°C). The collection has been assembled with the view to maximise uniqueness through the design and synthesis of novel and uncommon heterocyclic molecules, while adhering to the principles of bioactive molecule discovery.


    The compounds in this discovery collection have been either prepared in house through bioactive molecule discovery programs targeting pharmaceutical, veterinary and agricultural therapeutic classes; or acquired from leading Australian and New Zealand academic laboratories.


    The purity of each compound is typically ≥ 90%.


    The discovery collection can be supplied in specific plated formats, and is available in standard SD file format for in silico exploration. Complete library descriptions including structure, molecular weight, cLogP, and purity can be made available for analysis.


    The discovery collection represents a unique and diverse collection of small ‘drug-like’ and ‘lead-like’ molecules that are available for screening. Its impressive range of structural diversity makes it an ideal source of new compounds for pharmaceutical discovery.


    We are able to resupply compounds. The price for resupply depends on the sample and the quantity required.

    Custom Libraries

    CSIRO has developed fragment screening and custom libraries for our partners, and screened those compounds using our SPR facilities.