Cytocybernetics makes the first truly plug and play dynamic clamp system for single cell voltage clamp. Attaching to any existing voltage clamp system, the Cybercyte is dedicated to simulating voltage gated currents in real-time. Markov and Hodgkin and Huxley type models are supported. The unique analog/digital architecture eliminates the chronic instabilities and high random latency errors associated with general purpose Windows based systems. In addition, the system can also be used to introduce currents from heterologously expressed channels to study the effects of kinetic mutations.