This mixed-reality activity will focus on the pathogenesis and management of patients with advanced non-melanoma skin cancers. In this program, we will look at pathogenic drivers of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) - including cellular signaling pathways and immune dysfunction, assess pathways for potential therapeutic approaches, and review available treatment options targeting these pathways in the management for cSCC and BCC.