D. E. Shaw Research is an independent research laboratory that conducts basic scientific research in the field of computational biochemistry. Our group is currently focusing on molecular simulations involving proteins and other biological macromolecules of potential interest from scientific and pharmaceutical perspectives. Members of the lab include computational chemists and biologists, computer scientists and applied mathematicians, and computer architects and engineers, all working collaboratively within a tightly coupled interdisciplinary research environment. Our lab has designed and constructed multiple generations of a massively parallel supercomputer called Anton, specifically for the execution of molecular dynamics (MD) simulations. Each Anton supercomputer can simulate a single MD trajectory as much as a millisecond or so in duration -- a timescale at which biologically significant phenomena occur. Anton has already generated the world's longest MD trajectory.