Systag, System Technik AG

Rüschlikon,  Zurich 
Switzerland
http://www.systag.ch
  • Booth: 2011

SYSTAG is specialised in pharmaceutical and Fine chemicals process automation from millilitre scale to kilo. Our innovative systems like FlexyPAT - Controlled Lab Reactor - and FlexyCUBE - Parallel Synthesis Reactors - are designed to provide easy scale up in R&D for chemical engineering, process research / optimisation, including thermal process safety. This range of tools and equipment are also designed to make laboratory processes more reliable, more economical and safer. We are sure our products and services generating a high degree of added value for your custom synthesis either in your process development, process optimisation or Scale-Up and associated thermal process safety analysis. We are a Swiss-based company, quality products and exceptional customer service are OUR trademark – and YOUR gain.

Brands: FlexyCUBE multi-reactor applications for parallel process optimisation FlexyPAT flexible automated laboratory reactor Calo2310 all-in-one reaction calorimeter with heat flow and heat balance method


 Press Releases

  • Rüschlikon, Zürich: – Mike Mandlehr, the Director of Sales & Marketing of Swiss-based fine chemicals and pharmaceutical process automation specialist SYSTAG, has taken part in a Question and Answer session, ‘Optimizing development resources for efficient product development’.

    Mr. Mandlehr answers key questions about the company and its laboratory automation systems, to demonstrate how efficient process R&D have become crucial for modern contract and API manufacturers, with the need to push through new products/processes to market readiness ever faster, with full safety testing, overcoming barriers of scarce development resources and pressures of routine administration and regulatory requirement to keep detailed records.

    Q: Who and what is SYSTAG?

    MM: SYSTAG stands for System Technik AG. We’re a Swiss-based company, founded in 1965 to provide systems automation solutions for the chemicals and pharmaceuticals industries. We specialize in automation of Fine Chemicals and Pharmaceutical processes from milliliter Lab-Scale up to Kilo-Lab-Scale. Our strongest USPs are in the innovative nature of our technologies, our very high construction and engineering standards and in the scalability and flexibility of our systems, designed to provide easy scale-up at every key stage from development through piloting to production control technology.

    Q: Why do R&D laboratories need greater automation?

    MM: Well, nowadays, efficient process research and development are, more than ever, an absolute must for contract manufacturers and API manufacturers. New products and processes need to be pushed through to market readiness faster and faster. However, development departments suffer from a shortage of resources and the available employees are often overburdened with administrative tasks. So it is no wonder that in many cases there is less time available for serious process development. Time-consuming routine work such as dosing, tempering and similar control tasks can be left to an automated laboratory reactor while limited human resources can then be used for more important work.

    Q: What are the benefits of Controlled Lab Reactors?

    MM: SYSTAG’s Controlled Lab Reactor FlexyPAT and the Parallel Synthesis Workstation FlexyCUBE can help chemists greatly, providing systematic laboratory automation from the beginning of the development process. These controlled lab reactor systems deliver two main advantages.

    First, their ability to provide comprehensive data capture and visualization make it possible to spot complex interrelationships even at a very early stage of development. Second, processes become much more robust and reproducible, eliminating variance in artifacts as well as human performance. In both these ways, more widespread use of lab automation, based on customized controlled lab reactors, enables enormous increases in efficiency of entire groups or departments.

    There’s a third aspect to consider: regulation. Nowadays, strategic process optimization in Quality by Design (QbD) or statistic Design of Experiments (DoE) has become indispensable for fast and efficient process research and process optimization. As part of the regulatory trend, data traceability is becoming increasingly overt in very early stage development. Without closely controlled lab reactors, it isn’t possible to meet these new norms and standards.

    Q: What are typical applications for your FlexyCUBE and FlexyPAT controlled lab reactors?

    MM: Well, basically one obtains an advantage from using automated lab reactors wherever temperature controlled jacketed lab reactors or round bottom flask are used to perform synthetic reactions.

    This ranges from chemical and pharmaceutical process research at milliliter-scale, through process development and thermal safety investigations for reaction calorimetry, all the way up to kilogram scale production.

    Typical applications are for example, hydrogenation with elaborate inertisation cycles, or crystallization optimization with recurrent heating and cooling loops, with regard for Meta-Stable Zone determination. This involves, particularly when combined with an on-line turbidity meter, determining the turbidity point and solubility of a product at different concentrations as functions of temperature. If you want to do this using a conventional, manual, method, you’ll need a large number of tests with meticulous logging and subsequent evaluation. A ‘controlled laboratory’ on the other hand, performs all necessary steps fully automatically. These include not only the various heating and cooling cycles, but also the required dosage between each cycle to obtain solubility of a product at different concentrations. Here, time saving is an important factor in such applications, along with greater reproducibility.

    To return to the hydrogenation example, we should also remember that, in addition to economy, safety is also significant factor. For hydrogenation, and indeed most gas reactions generally, the inertisation – reducing oxygen sensitivity – is often of paramount importance. With an automated lab reactor, all these phases can be carried out under so-called standard operation procedure (SOP) autonomously while maintaining quality at every stage. Furthermore, the exact recording of quantity of gas in hydrogenations is crucial.

    In addition to the precise temperature control and pressure control the mixing (stir efficiency) at different stirring speeds, and thus the gas absorption, are essential, if for example, various catalysts are examined (catalyst screening). It is almost impossible to control and record all these parameters in a reproducible and continuous manner without laboratory automation. And here, our proven SYSTAG solutions show their strengths.

    Q: How would you summarize the strengths of SYSTAG’s automated systems?

    MM: SYSTAG develops modular and innovative tools for automating chemical synthesis reactions, from laboratory scale through to scale-up or mini-pilot. SYSTAG has more than 50 years of experience of applications and automation, based on our close cooperation with the chemical and pharmaceutical industries. We develop and offer customer-specific, systematic laboratory automation, all from a single source. Our knowhow becomes a strategic advantage for our customers, with the Swiss build quality of our products and exceptional customer service forming our brand value and our customers’ gain.


 Products

  • FlexyCUBE - Parallel Synthesis Work station
    FlexyCUBE is a modular concept for chemical process development. It is engineered to suit all laboratory automation needs and allows laboratories to develop drugs, API’s or intermediates easier, faster and cheaper.<br />...

  • FlexyCUBE includes all necessary tools and functions to enable users to simulate complex processes, including hydrogenation, Grignard or Friedel-Crafts reactions, acetylation, nitration and esterification and many more.

    It provides a powerful tool whenever the laboratory needs to process multiple experiments reliably, in a short time and under absolutely reproducible conditions. It offers a very wide range of applications, with projects being controlled individually or in parallel, for example for Design of Experiment (DoE) projects.

    Simplified handling

    Reactors are easily detached from the heating/cooling system and exchanged, allowing the user to quickly swap reactors or employ them for further experiments. The two-part reactor approach with hermetically separated temperature jacket eliminates troublesome emptying and filling of the temperature control system and messy dripping of the heating/cooling medium. See also https://www.systag.ch/products/controlled-lab-reactors/flexycube.html

  • ePAT - enhanced jacketed reactor with data capture
    ePAT is a quick, easy and inexpensive solution for automating control of double jacketed reactors for research and development. It provides a cost-effective entry route into automation technology, allowing users to optimize their synthesis and processes....

  • Combining Plug & Play interconnectability with exceptional ease of operation, SYSTAG ePAT can control an almost unlimited number of jacketed reactors in the chemical laboratory, with the option of integrating a wide array of laboratory devices.

    ePAT’s integral safety concept guarantees uninterrupted monitoring, specially designed for unsupervised operation day and night.

    The ePAT system does not need a conventional computer, handing over all regulation and protocol tasks to its integrated eController.

    The basic ePAT configuration offers a wide range of functions for performing routine tasks such as tempering, dosing, stirring, or adjusting pH with greater reliability and reproducibility.

    Built in software features include:

    • Logging – online trend and data capture of all events
    • Stirring with logging of torque measurement
    • Five segment multi-stage temperature control
    • Two dosages, temperature-monitored pH-measurement and control
    • Safety monitoring
    • Pt-100, RS232, analog input/output signals
  • FlexyPlant - Safe Scale-Up solution
    FlexyPlant offers customer-specific solutions for automating kilo-labs and pilot plants as well as application-specific reactors....

  • The challenge in the automation of process engineering systems is based on the specific needs of the user and the required safety elements. A flexible but production-oriented process control system through a suitable safety concept with the possibility to react to deviations during the process, are a prerequisite for automation technology in the small-scale production.

    Customized solutions for the complete automation of kilo-lab or mini-pilots with reactor sizes up to 250 L and turnkey complete solutions (systems, sensors and fittings) are the strengths of SYSTAG (see also https://www.systag.ch/products/plant-control-systems/flexyplant.html).